Palladium-Spermine Complex (Pd<sub>2</sub>Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells

Palladium-Spermine Complex (Pd<sub>2</sub>Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is an aggressive breast carcinoma with a poor prognosis. Current treatment options with platinum-(Pt)-based chemotherapeutics are limited by toxicity/acquired resistance, which has prompted the search for novel metal-based compounds. Dinuclear palladium(II)-sperm...

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Bibliographic Details
Main Authors: Martin Vojtek, Maria P. M. Marques, Ana L. M. Batista de Carvalho, Helder Mota-Filipe, Isabel M. P. L. V. O. Ferreira, Carmen Diniz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Medical Sciences Forum
Subjects:
breast cancer
TNBC
cisplatin
Pd2Spm
Pd(II)-based drugs
Online Access:https://www.mdpi.com/2673-9992/14/1/142

Internet

https://www.mdpi.com/2673-9992/14/1/142

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