Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy

Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy

Abstract Background Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease of the aged and a prominent comorbidity of Alzheimer’s disease (AD). CAA can promote a variety of vascular-related pathologies including neuroinflammation, cerebral infarction, and hemorrhages, which can...

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Bibliographic Details
Main Authors: Xiaoyue Zhu, Joshua Hatfield, Joseph K. Sullivan, Feng Xu, William E. Van Nostrand
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Neuroinflammation
Subjects:
Cerebral amyloid angiopathy
Alzheimer’s disease
Transgenic rats
Beta amyloid
Neuroinflammation
Perivascular stress
Online Access:http://link.springer.com/article/10.1186/s12974-020-01755-y

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http://link.springer.com/article/10.1186/s12974-020-01755-y

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