Virus Mimetic Poly (I:C)-Primed Airway Exosome-like Particles Enter Brain and Induce Inflammatory Cytokines and Mitochondrial Reactive Oxygen Species in Microglia

Virus Mimetic Poly (I:C)-Primed Airway Exosome-like Particles Enter Brain and Induce Inflammatory Cytokines and Mitochondrial Reactive Oxygen Species in Microglia

Viral infections induce extracellular vesicles (EVs) containing viral material and inflammatory factors. Exosomes can easily cross the blood-brain barrier during respiratory tract infection and transmit the inflammatory signal to the brain; however, such a hypothesis has no experimental evidence. Th...

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Bibliographic Details
Main Authors: Deimantė Kulakauskienė, Deimantė Narauskaitė, Dovydas Gečys, Otilija Juknaitė, Lina Jankauskaitė, Aistė Masaitytė, Jurgita Šventoraitienė, Hermanas Inokaitis, Zoja Miknienė, Ilona Sadauskienė, Giedrius Steponaitis, Zbigniev Balion, Ramunė Morkūnienė, Neringa Paužienė, Dainius Haroldas Pauža, Aistė Jekabsone
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biology
Subjects:
airway cell exosomes
viral infection
microglia
mitochondria
reactive oxygen species
Online Access:https://www.mdpi.com/2079-7737/10/12/1359

Internet

https://www.mdpi.com/2079-7737/10/12/1359

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