Contribution of Chymase-Dependent Angiotensin II Formation to the Progression of Tubulointerstitial Fibrosis in Obstructed Kidneys in Hamsters

Contribution of Chymase-Dependent Angiotensin II Formation to the Progression of Tubulointerstitial Fibrosis in Obstructed Kidneys in Hamsters

Recent studies indicate a role of chymase in the regulation of angiotensin II (AngII) formation in cardiovascular and renal tissues. We investigated a possible contribution of chymase to AngII formation and to renal fibrosis in unilateral ureteral obstruction (UUO). Eight-week-old Syrian hamsters we...

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Bibliographic Details
Main Authors: Yu-Yan Fan, Akira Nishiyama, Yoshihide Fujisawa, Hiroyuki Kobori, Daisuke Nakano, Junji Matsuura, Naoki Hase, Hirofumi Hitomi, Hideyasu Kiyomoto, Hidenori Urata, Masakazu Kohno
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319311363

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http://www.sciencedirect.com/science/article/pii/S1347861319311363

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