Identification of potential therapeutic dual inhibitors of EGFR/HER2 in breast cancer

Identification of potential therapeutic dual inhibitors of EGFR/HER2 in breast cancer

Breast cancer (BC) is the leading cause of death among women worldwide. According to the Breast Cancer Research Foundation (BCRF), 25% of all cases of BC are positive for human epidermal growth factor receptor 2 (HER2), which is the most aggressive phenotype among the five BC subtypes. Previous stud...

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Bibliographic Details
Main Authors: Megha Jethwa, Aditi Gangopadhyay, Achintya Saha
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Dual inhibitor
EGFR
HER2
Pharmacophore model
Docking
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000153

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http://www.sciencedirect.com/science/article/pii/S2772417424000153

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