<i>A First-Class Degrader Candidate Targeting Both</i> KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination

<i>A First-Class Degrader Candidate Targeting Both</i> KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination

“Undruggable” targets such as KRAS are particularly challenging in the development of drugs. We devised a novel chemical knockdown strategy, CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) technology, which promotes protein degradation using small molecules (CANDDY molecules) that...

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Bibliographic Details
Main Authors: Etsuko Miyamoto-Sato, Satoshi Imanishi, Lijuan Huang, Shoko Itakura, Yoichi Iwasaki, Masamichi Ishizaka
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
target protein degradation
undruggable target
KRAS G12D
KRAS G12V
cancer
degrader
Online Access:https://www.mdpi.com/1420-3049/28/14/5600

Internet

https://www.mdpi.com/1420-3049/28/14/5600

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