Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas

Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas

IntroductionAdult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in gliomas remains poorly understood.MethodsIn this study, we characterized tumor-infiltrati...

Full description

Bibliographic Details
Main Authors: Claudia Carenza, Sara Franzese, Alessandra Castagna, Sara Terzoli, Matteo Simonelli, Pasquale Persico, Lorenzo Bello, Marco Conti Nibali, Federico Pessina, Paolo Kunderfranco, Clelia Peano, Simone Balin, Joanna Mikulak, Francesca Calcaterra, Raffaella Bonecchi, Benedetta Savino, Massimo Locati, Silvia Della Bella, Domenico Mavilio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
brain tumors
perioperative corticosteroids
immune suppressive tumor microenvironment
single cell-RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1074762/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1074762/full

Similar Items