Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles

Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles

Regio- and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone (10) were carried out with different mono-substituted, disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-3′-yl)-N-phenyl-isoxazolidines (16–22). Reactions...

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Bibliographic Details
Main Authors: Vishal Sharma, Raman Kalia, Tilak Raj, Vivek K. Gupta, Nitasha Suri, Ajit K. Saxena, Deepak Sharma, Surinderjit S. Bhella, Gurpinder Singh, Mohan Paul S. Ishar
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
3-Indolylisoxazolidines
3-Pyridylisoxazolidines
Bis-indoles
1,3-Dipolar cycloadditions
Modified nucleosides
Cytotoxic activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511001110

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http://www.sciencedirect.com/science/article/pii/S2211383511001110

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