Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Abstract Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction across the cellular membrane. However, cell-surface antigen-induced multimerizati...

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Bibliographic Details
Main Authors: Yan Sun, Xiu-Na Yang, Shuang-Shuang Yang, Yi-Zhu Lyu, Bing Zhang, Kai-Wen Liu, Na Li, Jia-Chen Cui, Guang-Xiang Huang, Cheng-Lin Liu, Jie Xu, Jian-Qing Mi, Zhu Chen, Xiao-Hu Fan, Sai-Juan Chen, Shuo Chen
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01686-z

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https://doi.org/10.1038/s41392-023-01686-z

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