Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes.

Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes.

Differentiated epithelial cells are an important source of infectious EBV virions in human saliva, and latent Epstein-Barr virus (EBV) infection is strongly associated with the epithelial cell tumor, nasopharyngeal carcinoma (NPC). However, it has been difficult to model how EBV contributes to NPC,...

Full description

Bibliographic Details
Main Authors: Deo R Singh, Scott E Nelson, Abigail S Pawelski, Juan A Cantres-Velez, Alisha S Kansra, Nicholas P Pauly, Jillian A Bristol, Mitchell Hayes, Makoto Ohashi, Alejandro Casco, Denis Lee, Stuart A Fogarty, Paul F Lambert, Eric C Johannsen, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010868

Internet

https://doi.org/10.1371/journal.ppat.1010868

Similar Items