Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes.

Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes.

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Differentiated epithelial cells are an important source of infectious EBV virions in human saliva, and latent Epstein-Barr virus (EBV) infection is strongly associated with the epithelial cell tumor, nasopharyngeal carcinoma (NPC). However, it has been difficult to model how EBV contributes to NPC,...

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Bibliographic Details
Main Authors: Deo R Singh, Scott E Nelson, Abigail S Pawelski, Juan A Cantres-Velez, Alisha S Kansra, Nicholas P Pauly, Jillian A Bristol, Mitchell Hayes, Makoto Ohashi, Alejandro Casco, Denis Lee, Stuart A Fogarty, Paul F Lambert, Eric C Johannsen, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010868

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https://doi.org/10.1371/journal.ppat.1010868

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