Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII

Selective inhibition of tumor-associated carbonic anhydrase (CA; EC 4.2.1.1) isoforms IX and XII is a crucial prerequisite to develop successful anticancer therapeutics. Herein, we confirmed the efficacy of the 3-nitrobenzoic acid substructure in the design of potent and selective carboxylic acid de...

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Bibliographic Details
Main Authors: Ylenia Cau, Daniela Vullo, Mattia Mori, Elena Dreassi, Claudiu T. Supuran, Maurizio Botta
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
carbonic anhydrase inhibitors (CAIs)
carboxylic acid
tumor-associated isoforms
isoform selectivity
molecular modeling
Online Access:https://www.mdpi.com/1420-3049/23/1/17

Internet

https://www.mdpi.com/1420-3049/23/1/17

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