The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats

The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats

Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary arterial pressure and right heart failure. Selective pulmonary vasodilators have improved the prognosis of PAH; however, they are not able to reverse pulmonary vascular remodeling. Therefore, a search for new treatment agen...

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Bibliographic Details
Main Authors: Hiroki Shoji, Yoko Yoshida, Takayuki Jujo Sanada, Akira Naito, Junko Maruyama, Erquan Zhang, Kengo Sumi, Seiichiro Sakao, Kazuo Maruyama, Hiroyoshi Hidaka, Koichiro Tatsumi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
pulmonary hypertension
Rho-associated protein kinase signaling
mammalian target of rapamycin signaling
animal model of pulmonary arterial hypertension
right ventricular remodeling
Online Access:https://www.mdpi.com/2073-4409/11/1/66

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https://www.mdpi.com/2073-4409/11/1/66

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