Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross

Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross

The oligoadenylate-synthetase (Oas) gene locus provides innate immune resistance to virus infection. In mouse models, variation in the Oas1b gene influences host susceptibility to flavivirus infection. However, the impact of Oas variation on overall innate immune programming and global gene expressi...

Full description

Bibliographic Details
Main Authors: Richard Green, Courtney Wilkins, Sunil Thomas, Aimee Sekine, Duncan M. Hendrick, Kathleen Voss, Renee C. Ireton, Michael Mooney, Jennifer T. Go, Gabrielle Choonoo, Sophia Jeng, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Shannon McWeeney, Michael Gale Jr.
Format: Article
Language:English
Published: Oxford University Press 2017-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Oas
flavivirus
viral infection
innate immunity
multiparental populations
Multi-parent Advanced Generation Inter-Cross (MAGIC)
MPP
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.041624

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.041624

Similar Items