Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer

Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer

<p>Abstract</p> <p>Background</p> <p>Successful treatment of solid tumors relies on the ability of drugs to penetrate into the tumor tissue.</p> <p>Methods</p> <p>We examined the correlation of panitumumab (an anti-epidermal growth factor [EGFR]...

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Bibliographic Details
Main Authors: Freeman Daniel J, McDorman Kevin, Ogbagabriel Selam, Kozlosky Carl, Yang Bing-Bing, Doshi Sameer, Perez-Ruxio Juan, Fanslow William, Starnes Charlie, Radinsky Robert
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Molecular Cancer
Subjects:
EGFR
Monoclonal antibody
Xenografts
Pharmacokinetics
Pharmacodynamics
Online Access:http://www.molecular-cancer.com/content/11/1/47

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