Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1α-dependent tumor hypoxia adaptation

Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1α-dependent tumor hypoxia adaptation

Abstract Background Non-redundant properties such as hypoxia and acidosis promote tumor metabolic adaptation and limit anti-cancer therapies. The key to the adaptation of tumor cells to hypoxia is the transcriptional and stable expression of hypoxia-inducible factor-1 alpha (HIF-1α). The phosphoryla...

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Bibliographic Details
Main Authors: Jie Liu, Xiaochun Hu, Lei Feng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi, Chunyan Dong
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Nanobiotechnology
Subjects:
Hypoxia
CAIX
Intracellular acidification
mTOR signal
Hypoxia adaptation
Online Access:https://doi.org/10.1186/s12951-022-01394-w

Internet

https://doi.org/10.1186/s12951-022-01394-w

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