GSTT1/GSTM1 deficiency aggravated cisplatin-induced acute kidney injury via ROS-triggered ferroptosis

GSTT1/GSTM1 deficiency aggravated cisplatin-induced acute kidney injury via ROS-triggered ferroptosis

IntroductionCisplatin is a widely used chemotherapeutic agent prescribed to treat solid tumors. However, its clinical application is limited because of cisplatin- induced nephrotoxicity. A known complication of cisplatin is acute kidney injury (AKI). Deletion polymorphisms of GSTM1 and GSTT1, member...

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Bibliographic Details
Main Authors: Peipei Li, Duopin Li, Yanfang Lu, Shaokang Pan, Fei Cheng, Shen Li, Xiaonan Zhang, Jinling Huo, Dongwei Liu, Zhangsuo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
AKI
cisplatin
GSTT1
GSTM1
ROS
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457230/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457230/full

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