Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis

Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis

Abstract Aberrant expansion of KRT5+ basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5+ cells in IPF have not been delineated. Here, we re...

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Bibliographic Details
Main Authors: Richard J. Hewitt, Franz Puttur, David C. A. Gaboriau, Frédéric Fercoq, Maryline Fresquet, William J. Traves, Laura L. Yates, Simone A. Walker, Philip L. Molyneaux, Samuel V. Kemp, Andrew G. Nicholson, Alexandra Rice, Edward Roberts, Rachel Lennon, Leo M. Carlin, Adam J. Byrne, Toby M. Maher, Clare M. Lloyd
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41621-y

Internet

https://doi.org/10.1038/s41467-023-41621-y

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