In Vitro and In Vivo Crosstalk between Type I IFN and IL-8 Responses in SARS-CoV-2 Infection

In Vitro and In Vivo Crosstalk between Type I IFN and IL-8 Responses in SARS-CoV-2 Infection

COVID-19 patients show characteristic over-expression of different cytokines that may interfere with the interferon (IFN) response, delaying its production. Within the overexpressed cytokines, IL-8 plays a key role, and it may impede IFN-I activation. PBMC from eight healthy donors were exposed to 2...

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Bibliographic Details
Main Authors: Mirella Biava, Stefania Notari, Germana Grassi, Licia Bordi, Eleonora Tartaglia, Chiara Agrati, Eleonora Cimini, Giuseppe Sberna, Emanuele Nicastri, Andrea Antinori, Enrico Girardi, Francesco Vaia, Fabrizio Maggi, Eleonora Lalle
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Microorganisms
Subjects:
IFN-I
IL-8
SARS-CoV-2
crosstalking
antagonism
COVID-19
Online Access:https://www.mdpi.com/2076-2607/11/11/2787

Internet

https://www.mdpi.com/2076-2607/11/11/2787

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