Structural basis for self-discrimination by neoantigen-specific TCRs

Structural basis for self-discrimination by neoantigen-specific TCRs

Abstract T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of neoAg from somatic mutations is a major focus of...

Full description

Bibliographic Details
Main Authors: John P. Finnigan, Jenna H. Newman, Yury Patskovsky, Larysa Patskovska, Andrew S. Ishizuka, Geoffrey M. Lynn, Robert A. Seder, Michelle Krogsgaard, Nina Bhardwaj
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46367-9

Internet

https://doi.org/10.1038/s41467-024-46367-9

Similar Items