The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells

The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells

Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. However, the molecular mechanisms involved in the cytokine-mediated crosstalk between mesenchymal stem cells (MSCs) and AML cells are largely unknown. Le...

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Bibliographic Details
Main Authors: Håkon Reikvam, Annette K. Brenner, Karen Marie Hagen, Knut Liseth, Silje Skrede, Kimberley Joanne Hatfield, Øystein Bruserud
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Research
Subjects:
Acute myeloid leukemia
Mesenchymal stem cells
Cytokines
Gene expression
Chemokines
NFκB
Toll like receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S187350611500121X

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http://www.sciencedirect.com/science/article/pii/S187350611500121X

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