Synthesis of Cobalt Bis(Dicarbollide)—Curcumin Conjugates for Potential Use in Boron Neutron Capture Therapy

Synthesis of Cobalt Bis(Dicarbollide)—Curcumin Conjugates for Potential Use in Boron Neutron Capture Therapy

A series of novel cobalt bis(dicarbollide)—curcumin conjugates were synthesized. Two conjugates were obtained through the nucleophilic ring-opening reaction of the 1,4-dioxane and tetrahydropyran derivatives of cobalt bis(dicarbollide) with the OH group of curcumin, and using two equiv. of the oxoni...

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Bibliographic Details
Main Authors: Lyubov G. Dezhenkova, Anna A. Druzina, Yulia L. Volodina, Nadezhda V. Dudarova, Natalia A. Nekrasova, Olga B. Zhidkova, Mikhail A. Grin, Vladimir I. Bregadze
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
curcumin
cobalt bis(dicarbollide)
polyhedral boron compounds
cell viability
intracellular accumulation
Online Access:https://www.mdpi.com/1420-3049/27/14/4658

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https://www.mdpi.com/1420-3049/27/14/4658

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