Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells

Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells

The loss of mitochondrial function impairs intracellular energy production and potentially results in chronic liver disease. Increasing evidence suggests that mitochondrial dysfunction in hepatocytes contributes to the activation of hepatic stellate cells (HSCs), thereby resulting in hepatic fibroge...

Full description

Bibliographic Details
Main Authors: Wonhee Hur, Byung Yoon Kang, Sung Min Kim, Gil Won Lee, Jung-Hee Kim, Min-Kyung Nam, Hyangshuk Rhim, and Seung Kew Yoon
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
mitochondrial function
hepatic fibrogenesis
HtrA2/Omi
reactive oxygen species stress
mitochondrial homeostasis
Online Access:https://www.mdpi.com/2073-4409/8/10/1119

Internet

https://www.mdpi.com/2073-4409/8/10/1119

Similar Items