Valproic Acid Attenuates Traumatic Brain Injury-Induced Inflammation in Vivo: Involvement of Autophagy and the Nrf2/ARE Signaling Pathway

Valproic Acid Attenuates Traumatic Brain Injury-Induced Inflammation in Vivo: Involvement of Autophagy and the Nrf2/ARE Signaling Pathway

Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant...

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Bibliographic Details
Main Authors: Xiangrong Chen, Handong Wang, Mengliang Zhou, Xiang Li, Zhongning Fang, Hongzhi Gao, Yasong Li, Weipeng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
traumatic brain injury
valproic acid
HDAC3
microglia
inflammatory
autophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00117/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00117/full

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