E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL

E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL

Targeted disruption of E2f2 in mice causes T-cell hyperactivation and a disproportionate cell cycle entry upon stimulation. However, <i>E2f2</i><sup>−/−</sup> mice do not develop a lymphoproliferative condition. We report that E2f2 plays a Fas-dependent anti-apoptotic functio...

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Bibliographic Details
Main Authors: Noor Mustafa, Jone Mitxelena, Arantza Infante, Olatz Zenarruzabeitia, Ainhoa Eriz, Ainhoa Iglesias-Ara, Ana M. Zubiaga
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
E2f
apoptosis
Fas
FasL
T lymphocytes
immune disorder
Online Access:https://www.mdpi.com/1422-0067/23/1/311

Internet

https://www.mdpi.com/1422-0067/23/1/311

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