Sesquiterpene Lactone Deoxyelephantopin Isolated from <i>Elephantopus scaber</i> and Its Derivative DETD-35 Suppress BRAF<sup>V600E</sup> Mutant Melanoma Lung Metastasis in Mice

Sesquiterpene Lactone Deoxyelephantopin Isolated from <i>Elephantopus scaber</i> and Its Derivative DETD-35 Suppress BRAF<sup>V600E</sup> Mutant Melanoma Lung Metastasis in Mice

Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, the development of new therapeutic agents for metastatic melanoma are urgently required. In this study, we created a lung-seeking A375LM5<...

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Bibliographic Details
Main Authors: Biljana Cvetanova, Meng-Yi Li, Chung-Chih Yang, Pei-Wen Hsiao, Yu-Chih Yang, Jia-Hua Feng, Ya-Ching Shen, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
BRAF<sup>V600E</sup> metastatic melanoma
deoxyelephantopin
DETD-35
oxidative stress
mitochondria dysfunction
Online Access:https://www.mdpi.com/1422-0067/22/6/3226

Internet

https://www.mdpi.com/1422-0067/22/6/3226

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