Hypoxia increases KIAA1199/CEMIP expression and enhances cell migration in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by dense desmoplasia and hypoxic microenvironment. Our previous reports demonstrated that hyaluronan (HA), especially low-molecular-weight HA, provides a favourable microenvironment for PDAC progression. However, the effect of hypoxia...

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Bibliographic Details
Main Authors: Takuya Oba, Norihiro Sato, Yasuhiro Adachi, Takao Amaike, Yuzan Kudo, Atsuhiro Koga, Shiro Kohi, Keiji Hirata
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97752-z