Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses.
Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish and mice. In zebrafish, retinal regeneration is innate and robust, resulting in the replacement of lost neurons and restoration of visual function. In mice, exogenous stimulation of MG is required to reveal...
Main Authors: | Kevin Emmerich, Steven L Walker, Guohua Wang, David T White, Anneliese Ceisel, Fang Wang, Yong Teng, Zeeshaan Chunawala, Gianna Graziano, Saumya Nimmagadda, Meera T Saxena, Jiang Qian, Jeff S Mumm |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-10-01
|
Series: | PLoS Genetics |
Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010905&type=printable |
Similar Items
-
Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina
by: Kevin Emmerich, et al.
Published: (2023-05-01) -
Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.
by: Yong Teng, et al.
Published: (2011-01-01) -
Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish
by: Sol Pose-Méndez, et al.
Published: (2023-04-01) -
Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line
by: Ellen Megerson, et al.
Published: (2024-01-01) -
Labelling and targeted ablation of specific bipolar cell types in the zebrafish retina
by: Ellingsen Staale, et al.
Published: (2009-08-01)