Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM), a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes, accounts for 20% of sudden cardiac death and lacks effective treatment. It is often caused by mutations in desmosome proteins, with Desmoglein-2 (DSG2) mutations as a common e...

Full description

Bibliographic Details
Main Authors: Yubi Lin, Ruonan Liu, Yanling Huang, Zhe Yang, Jianzhong Xian, Jingmin Huang, Zirui Qiu, Xiufang Lin, Mengzhen Zhang, Hui Chen, Huadong Wang, Jiana Huang, Geyang Xu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Arrhythmogenic cardiomyopathy
Desmosome
Desmoglein2
Heart failure
Lipid accumulation
mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522002404

Internet

http://www.sciencedirect.com/science/article/pii/S2211383522002404

Similar Items