Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a promising therapeutical approach for Parkinson’s disease (PD). Herein, 24 melatonin analogues (<b>3a</b>–<b&...

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Bibliographic Details
Main Authors: Ahmed Elkamhawy, Jiyu Woo, Noha A. Gouda, Jushin Kim, Hossam Nada, Eun Joo Roh, Ki Duk Park, Jungsook Cho, Kyeong Lee
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Antioxidants
Subjects:
bioactive molecules
oxidative stress
neurodegeneration
brain health
Parkinson’s disease
MAO-B
Online Access:https://www.mdpi.com/2076-3921/10/10/1604

Internet

https://www.mdpi.com/2076-3921/10/10/1604

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