The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent. Here, we discuss how the protein structure and dynamic ar...

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Bibliographic Details
Main Authors: Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García, Steve P Watson
Format: Article
Language:English
Published: Taylor & Francis Group 2021-08-01
Series:Platelets
Subjects:
Online Access:http://dx.doi.org/10.1080/09537104.2021.1906407