Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

Abstract Background Age-related changes in the cerebrovasculature, including blood–brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothelial cells that constitute the cerebrovasculature may play key roles in...

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Bibliographic Details
Main Authors: Hyejeong Kim, Minyoung Noh, Haiying Zhang, Yeomyeong Kim, Songyi Park, Jeongeun Park, Young-Guen Kwon
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Fluids and Barriers of the CNS
Subjects:
CU06-1004
Blood–brain barrier
Aging
Brain microvascular endothelial cell (BMEC)
Reactive oxygen species (ROS)
Cerebrovasculature
Online Access:https://doi.org/10.1186/s12987-023-00410-x

Internet

https://doi.org/10.1186/s12987-023-00410-x

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