Modeling the role of HIF in the regulation of metabolic key genes LDH and PDH: Emergence of Warburg phenotype
Abstract Oxygenation of tumors and the effect of hypoxia on cancer cell metabolism is a widely studied subject. Hypoxia‐inducible factor (HIF), the main actor in the cell response to hypoxia, represents a potential target in cancer therapy. HIF is involved in many biological processes such as cell p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | Computational and Systems Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cso2.1040 |