In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.

In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.

Cancer cells respond to stress by activating a variety of survival signaling pathways. A disintegrin and metalloproteinase (ADAM) 9 is upregulated during cancer progression and hormone therapy, functioning in part through an increase in reactive oxygen species. Here, we present in vitro and in vivo...

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Main Authors: Che-Ming Liu, Chia-Ling Hsieh, Yun-Chi He, Sen-Jei Lo, Ji-An Liang, Teng-Fu Hsieh, Sajni Josson, Leland W K Chung, Mien-Chie Hung, Shian-Ying Sung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3547060?pdf=render

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http://europepmc.org/articles/PMC3547060?pdf=render

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