PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer

PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer

IntroductionChimeric Antigen Receptor (CAR) T cell therapy has demonstrated remarkable success in treating hematological malignancies. However, its efficacy against solid tumors, including cervical cancer, remains a challenge. Hypoxia, a common feature of the tumor microenvironment, profoundly impac...

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Bibliographic Details
Main Authors: Ahmad Reza Panahi Meymandi, Behnia Akbari, Tahereh Soltantoyeh, Zahra Shahosseini, Mina Hosseini, Jamshid Hadjati, Hamid Reza Mirzaei
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Oncology
Subjects:
CAR T cell therapy
pharmacological targeting
HIF-1α
PX-478
cervical cancer
T cell exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1357801/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1357801/full

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