The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole

The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole

Albendazole (ABZ) is an anthelmintic frequently used to treat haemonchosis, a common parasitosis of ruminants caused by the gastrointestinal nematode Haemonchus contortus. This parasite is able to protect itself against ABZ via the formation of inactive ABZ-glycosides. The present study was designed...

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Bibliographic Details
Main Authors: Diana Dimunová, Martina Navrátilová, Pavlína Kellerová, Martin Ambrož, Lenka Skálová, Petra Matoušková
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
UGT inhibitors
Anthelmintic resistance
Benzimidazoles
Glycosylation
Detoxification
Nematodes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320722000124

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http://www.sciencedirect.com/science/article/pii/S2211320722000124

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