Mechanosensitive expression of the mesenchymal subtype marker connective tissue growth factor in glioblastoma

Mechanosensitive expression of the mesenchymal subtype marker connective tissue growth factor in glioblastoma

Abstract Mechanical forces created by the extracellular environment regulate biochemical signals that modulate the inter-related cellular phenotypes of morphology, proliferation, and migration. A stiff microenvironment induces glioblastoma (GBM) cells to develop prominent actin stress fibres, take o...

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Bibliographic Details
Main Authors: Thomas James Grundy, Louise Orcheston-Findlay, Eshana de Silva, Thuvarahan Jegathees, Victoria Prior, Farhana Amy Sarker, Geraldine Margaret O’Neill
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19175-8

Internet

https://doi.org/10.1038/s41598-022-19175-8

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