Thyroid Hormone Induces Oral Cancer Growth via the PD-L1-Dependent Signaling Pathway

Thyroid Hormone Induces Oral Cancer Growth via the PD-L1-Dependent Signaling Pathway

Oral cancer is a fatal disease, and its incidence in Taiwan is increasing. Thyroid hormone as L-thyroxine (T<sub>4</sub>) stimulates cancer cell proliferation via a receptor on integrin αvβ3 of plasma membranes. It also induces the expression of programmed death-ligand 1 (PD-L1) and cell...

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Bibliographic Details
Main Authors: Kuan-Wei Su, Hung-Yun Lin, Hsien-Chung Chiu, Shin-Yu Shen, Chun A. ChangOu, Dana R. Crawford, Yu-Chen S. H. Yang, Ya-Jung Shih, Zi-Lin Li, Haw-Ming Huang, Jaqueline Whang-Peng, Yih Ho, Kuan Wang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
thyroxine
oral cancer
PD-L1
β-catenin
Online Access:https://www.mdpi.com/2073-4409/11/19/3050

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