Dissecting Human Gonadal Cell Lineage Specification and Sex Determination Using A Single-cell RNA-seq Approach

Dissecting Human Gonadal Cell Lineage Specification and Sex Determination Using A Single-cell RNA-seq Approach

Gonadal somatic cells are the main players in gonad development and are important for sex determination and germ cell development. Here, using a time-series single-cell RNA sequencing (scRNA-seq) strategy, we analyzed fetal germ cells (FGCs) and gonadal somatic cells in human embryos and fetuses. Cl...

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Bibliographic Details
Main Authors: Rui Wang, Xixi Liu, Li Li, Ming Yang, Jun Yong, Fan Zhai, Lu Wen, Liying Yan, Jie Qiao, Fuchou Tang
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Human gonad
scRNA-seq
Turner syndrome
Leydig-Sertoli cell–cell interaction
Gonocyte-to-spermatogonium transition
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022922000389

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http://www.sciencedirect.com/science/article/pii/S1672022922000389

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