The role of m6A RNA methylation in human cancer
Abstract N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-019-1033-z |
| _version_ | 1818144061840687104 |
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| author | Xiao-Yu Chen Jing Zhang Jin-Shui Zhu |
| author_facet | Xiao-Yu Chen Jing Zhang Jin-Shui Zhu |
| author_sort | Xiao-Yu Chen |
| collection | DOAJ |
| description | Abstract N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writers”), reverted by the demethylases (FTO and ALKBH5, termed as “erasers”) and recognized by m6A binding proteins (YTHDF1/2/3, IGF2BP1 and HNRNPA2B1, termed as “readers”). Acumulating evidence shows that, m6A RNA methylation has an outsize effect on RNA production/metabolism and participates in the pathogenesis of multiple diseases including cancers. Until now, the molecular mechanisms underlying m6A RNA methylation in various tumors have not been comprehensively clarified. In this review, we mainly summarize the recent advances in biological function of m6A modifications in human cancer and discuss the potential therapeutic strategies. |
| first_indexed | 2024-12-11T11:41:35Z |
| format | Article |
| id | doaj.art-c65004f7f185459bb8afbd9d4468a6c0 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-11T11:41:35Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-c65004f7f185459bb8afbd9d4468a6c02022-12-22T01:08:36ZengBMCMolecular Cancer1476-45982019-05-011811910.1186/s12943-019-1033-zThe role of m6A RNA methylation in human cancerXiao-Yu Chen0Jing Zhang1Jin-Shui Zhu2Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writers”), reverted by the demethylases (FTO and ALKBH5, termed as “erasers”) and recognized by m6A binding proteins (YTHDF1/2/3, IGF2BP1 and HNRNPA2B1, termed as “readers”). Acumulating evidence shows that, m6A RNA methylation has an outsize effect on RNA production/metabolism and participates in the pathogenesis of multiple diseases including cancers. Until now, the molecular mechanisms underlying m6A RNA methylation in various tumors have not been comprehensively clarified. In this review, we mainly summarize the recent advances in biological function of m6A modifications in human cancer and discuss the potential therapeutic strategies.http://link.springer.com/article/10.1186/s12943-019-1033-zN6-methyladenosineCancerRNA methylationPrognosisGrowthMetastasis |
| spellingShingle | Xiao-Yu Chen Jing Zhang Jin-Shui Zhu The role of m6A RNA methylation in human cancer Molecular Cancer N6-methyladenosine Cancer RNA methylation Prognosis Growth Metastasis |
| title | The role of m6A RNA methylation in human cancer |
| title_full | The role of m6A RNA methylation in human cancer |
| title_fullStr | The role of m6A RNA methylation in human cancer |
| title_full_unstemmed | The role of m6A RNA methylation in human cancer |
| title_short | The role of m6A RNA methylation in human cancer |
| title_sort | role of m6a rna methylation in human cancer |
| topic | N6-methyladenosine Cancer RNA methylation Prognosis Growth Metastasis |
| url | http://link.springer.com/article/10.1186/s12943-019-1033-z |
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