Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

Canonical Notch signaling is initiated when ligand binding induces proteolytic release of the intracellular part of Notch (ICN) from the cell membrane. ICN then travels into the nucleus where it drives the assembly of a transcriptional activation complex containing the DNA-binding transcription fact...

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Bibliographic Details
Main Authors: Cristina Del Bianco, Anastasia Vedenko, Sung Hee Choi, Michael F Berger, Leila Shokri, Martha L Bulyk, Stephen C Blacklow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2991368?pdf=render

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http://europepmc.org/articles/PMC2991368?pdf=render

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