Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration

Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration

Horses with inflammatory and infectious disorders are often treated with injectable heparin anticoagulants to prevent thrombotic complications. In humans, a new class of direct oral acting anticoagulants (DOAC) appear as effective as heparin, while eliminating the need for daily injections. Our stud...

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Bibliographic Details
Main Authors: Priscila B. S. Serpa, Marjory B. Brooks, Thomas Divers, Sally Ness, Ingvild Birschmann, Mark G. Papich, Tracy Stokol
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Veterinary Science
Subjects:
factor Xa
direct oral anticoagulant
EHV-1
platelet activation
equine
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2018.00304/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2018.00304/full

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