False gene and chromosome losses in genome assemblies caused by GC content variation and repeats

False gene and chromosome losses in genome assemblies caused by GC content variation and repeats

Abstract Background Many short-read genome assemblies have been found to be incomplete and contain mis-assemblies. The Vertebrate Genomes Project has been producing new reference genome assemblies with an emphasis on being as complete and error-free as possible, which requires utilizing long reads,...

Full description

Bibliographic Details
Main Authors: Juwan Kim, Chul Lee, Byung June Ko, Dong Ahn Yoo, Sohyoung Won, Adam M. Phillippy, Olivier Fedrigo, Guojie Zhang, Kerstin Howe, Jonathan Wood, Richard Durbin, Giulio Formenti, Samara Brown, Lindsey Cantin, Claudio V. Mello, Seoae Cho, Arang Rhie, Heebal Kim, Erich D. Jarvis
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Biology
Subjects:
Genomics
Gene structure
GC content
Genomic dark matter
Annotation
Online Access:https://doi.org/10.1186/s13059-022-02765-0

Internet

https://doi.org/10.1186/s13059-022-02765-0

Similar Items