Phase I study of intra-osseous co-transplantation of a single-unit cord blood and mesenchymal stromal cells with reduced intensity conditioning regimens

Phase I study of intra-osseous co-transplantation of a single-unit cord blood and mesenchymal stromal cells with reduced intensity conditioning regimens

Cord blood (CB) is a valuable graft source for patients undergoing allogeneic hematopoietic cell transplant (HCT) who lack human leukocyte antigen (HLA)-matched donors. However, single-unit CB-HCT is limited by the insufficient cell dose and slow engraftment. To overcome these limitations, we combin...

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Bibliographic Details
Main Authors: Jiasheng Wang, Farhad Sanati, Amin Firoozmand, Pingfu Fu, Merle Kolk, Jane Reese-Koc, Marcos de Lima, Kirsten Boughan, Brenda Cooper, Paolo Caimi, Molly Gallogly, Folashade Otegbeye, Benjamin Tomlinson, Leland Metheny
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
intra-osseous
cord blood
mesenchymal stromal cells
allogeneic hematopoietic cell transplantation
reduced intensity conditioning
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1186532/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1186532/full

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