Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

Abstract Background BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, the short remission time and high relapse rate of MM patients treated with BCMA CAR-T remain bottlenecks that limit long-term survival. Th...

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Bibliographic Details
Main Authors: Wei Li, Binglei Zhang, Weijie Cao, Wenli Zhang, Tiandong Li, Lina Liu, LinPing Xu, Fengcai Gao, Yanmei Wang, Fang Wang, Haizhou Xing, Zhongxing Jiang, Jianxiang Shi, Zhilei Bian, Yongping Song
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Experimental Hematology & Oncology
Subjects:
BCMA CAR-T
Multiple myeloma
Resistant mechanisms
ScRNA-seq
T cell exhaustion
Monocyte/macrophages
Online Access:https://doi.org/10.1186/s40164-023-00402-5

Internet

https://doi.org/10.1186/s40164-023-00402-5

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