Changes in Plasma Metabolic Signature upon Acute and Chronic Morphine Administration in Morphine-Tolerant Mice

Changes in Plasma Metabolic Signature upon Acute and Chronic Morphine Administration in Morphine-Tolerant Mice

Morphine administration causes system-level metabolic changes. Here, we show that morphine-tolerant mice exhibited distinct plasma metabolic signatures upon acute and chronic administration. We utilized a mouse model of morphine tolerance by exposing mice to increasing doses of the drug over 4 days....

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Bibliographic Details
Main Authors: Naseer A. Kutchy, Amelia Palermo, Rong Ma, Zhong Li, Alexandria Ulanov, Shannon Callen, Gary Siuzdak, Sabita Roy, Shilpa Buch, Guoku Hu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Metabolites
Subjects:
morphine
opioids
tolerance
metabolism
plasma
metabolomics
Online Access:https://www.mdpi.com/2218-1989/13/3/434

Internet

https://www.mdpi.com/2218-1989/13/3/434

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