Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice

Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice

Parkinson’s disease (PD) is a common neurodegenerative movement disorder with undetermined etiology. A major pathological hallmark of PD is the progressive degeneration of dopaminergic neurons in the substantia nigra. Loss-of-function mutations in the RAB39B gene, which encodes a neuronal-specific s...

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Bibliographic Details
Main Authors: Zijie Wang, Dingting Yang, Yiru Jiang, Yong Wang, Mengxi Niu, Chong Wang, Hong Luo, Huaxi Xu, Jingwen Li, Yun-wu Zhang, Xian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
MPTP
RAB39B
Pakinson’s disease
mouse behavior
dopaminergic neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1087823/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1087823/full

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