Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt‐tRNA mutations

Abstract Disorders of the mitochondrial genome cause a wide spectrum of disease, these present mainly as neurological and/or muscle related pathologies. Due to the intractability of the human mitochondrial genome there are currently no effective treatments for these disorders. The majority of the pa...

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Bibliographic Details
Main Authors: Hue Tran Hornig‐Do, Arianna Montanari, Agata Rozanska, Helen A Tuppen, Abdulraheem A Almalki, Dyg P Abg‐Kamaludin, Laura Frontali, Silvia Francisci, Robert N Lightowlers, Zofia M Chrzanowska‐Lightowlers
Format: Article
Language:English
Published: Springer Nature 2014-01-01
Series:EMBO Molecular Medicine
Subjects:
Online Access:https://doi.org/10.1002/emmm.201303202