Cofilin Inhibitor Improves Neurological and Cognitive Functions after Intracerebral Hemorrhage by Suppressing Endoplasmic Reticulum Stress Related-Neuroinflammation

Cofilin Inhibitor Improves Neurological and Cognitive Functions after Intracerebral Hemorrhage by Suppressing Endoplasmic Reticulum Stress Related-Neuroinflammation

Neuroinflammation after intracerebral hemorrhage (ICH) is a crucial factor that determines the extent of the injury. Cofilin is a cytoskeleton-associated protein that drives neuroinflammation and microglia activation. A novel cofilin inhibitor (CI) synthesized and developed in our lab has turned out...

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Bibliographic Details
Main Authors: Daniyah A. Almarghalani, Ghaith A. Bahader, Mohammad Ali, L. M. Viranga Tillekeratne, Zahoor A. Shah
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
cofilin inhibitor
ICH
neuroinflammation
microglial activation
post-stroke cognitive impairment
cofilin rods/aggregates
Online Access:https://www.mdpi.com/1424-8247/17/1/114

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https://www.mdpi.com/1424-8247/17/1/114

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