Galectin-9 regulates the threshold of B cell activation and autoimmunity

Despite the mechanisms of central and peripheral tolerance, the mature B cell compartment contains cells reactive for self-antigen. How these cells are poised not to respond and the mechanisms that restrain B cell responses to low-affinity endogenous antigens are not fully understood. Here, we demon...

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Bibliographic Details
Main Authors: Logan K Smith, Kareem Fawaz, Bebhinn Treanor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/64557