20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways

20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways

Osteolysis is a principal reason for arthroplasty failure like aseptic loosening induced by Titanium (Ti) particle. It is a challenge for orthopedic surgeons. Recent researches show that 20(S)-protopanaxadiol can inhibit inflammatory cytokine release in vitro. This study aims to assess the effect of...

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Bibliographic Details
Main Authors: Chenhao Pan, Haojie Shan, Tianyi Wu, Wei Liu, Yiwei Lin, Wenyang Xia, Feng Wang, Zubin Zhou, Xiaowei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
inflammation
bone resorption
MAPK signaling
NF-κB signaling
20(S)-protopanaxadiol
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01538/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01538/full

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